Hitori Bocchi suffers from extreme social anxiety, she's not good at talking to people, takes pretty extreme actions, is surprisingly adept at avoiding people, her legs cramp when she overexerts herself, gets full of herself when alone, will vomit when exposed to extreme tension and often comes up with plans. Now she is entering middle school and her only friend, Yawara Kai, is attending a different school. This leaves Bocchi alone, surrounded by new classmates with whom she must make friends before Kai will talk to her again.
April. A young girl stands alone, acting suspiciously in front of the entrance to a middle school... That girl is Hitori Bocchi, a new first year student at the school. And starting today, she's going to become friends with everyone in her class... hopefully!
I made my very first friend, Nako-chan, mad!! But I don't know why she's mad or how to even apologize! What do I do?! What should I do...?! That's when--!
"I want to go home with Honshou-san. I want to go home with Honshou-san..." As Bocchi keeps muttering her desire, Nako offers her some advice: "First you need to go invite her."
"I've been searching for you this whole time. You can't fool my eyes." The road to school is full of danger! As Bocchi tries to hide her presence and make it to school she runs into a bright foreigner?!
Aru attempts to save face in front of her friend Hanako Yamada after she accidentally brings an elementary school backpack to school with her. Things become more difficult for her the next day when she ends up wearing a full elementary school uniform. Later, Aru is challenged to a tennis match by Nako, finding it difficult due to all the times she's been skipping tennis club.
Bocchi becomes nervous about presenting a haiku in front of her class while Nako ends up having to take supplemental lessons after failing her maths test. Meanwhile, Teruyo, trying to get over her fear of Nako, makes the assumption that Bocchi is a secret gang leader.
Feeling she needs to make one more friend before summer break starts, Bocchi attempts to befriend disciplinary committee member Kako Kurai, only to fail miserably. During summer break, the girls go to the pool, where Bocchi teaches Nako how to swim. When the girls go to karaoke afterwards, Bocchi comes across Kai, who is relieved to see that Bocchi has made some friends and remembers her promise to her. On the way home, Sotoka expresses her desire to become friends with Bocchi to the others.
After many hurdles, Bocchi manages to get on talking terms with Kako, only to learn that she has a policy against making any friends. The next day, as Bocchi helps Kako clean the classroom, Kako explains that her policy is to prove herself strong enough to live on her own. Meanwhile, Sotoka worries about asking to be Bocchi's friend while remaining as her apprentice. In the end, she decides to focus on her apprentice training to show her appreciation towards Bocchi.
During cooking class, Bocchi ends up having to work with an unfamiliar group of classmates. With some help from Aru, Bocchi manages to impress her group by making them some whipped cream for their pancakes. Afterwards, Bocchi works up the courage to introduce her friends to Kako before asking her to join her group for making curry during an outdoor class. After a successful curry, Kako acknowledges Bocchi's determination to become stronger and declares herself as her rival.
Strong Bocchi powers up! Today she's Super Strong Bocchi! And Sotoka becomes Super Strong Sotoka too! What's making her stronger than usual? ...Her shoe?? Natto?!
If she doesn't talk to all of her friends every day, they'll forget her! While Bocchi has more friends now, she has more worries too. What should she do to ensure she remains friends with everyone? Make her CD Debut?!
Finally... Finally... Bocchi has a smartphone! Now Bocchi can join the smartphone tap-tap group too. Yet first she takes her friend's advice and greets her phone. So when it responds and she asks it to be her friend...?